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Abstract #3317

Impaired blood flow and vascular reactivity in the choroid in diabetic mice

Eric R. Muir1, Saurav B. Chandra2, Divya Narayanan3, Nikolay P. Akimov4, René C. Rentería4,5, and Timothy Q. Duong1
1Radiology, Stony Brook University, Stony Brook, NY, United States, 2Icon Clinical Research Inc, North Wales, PA, United States, 3Ora Clinical, Andover, MA, United States, 4Ophthalmology, University of Texas Health Science Center, San Antonio, TX, United States, 5School of Osteopathic Medicine, University of the Incarnate Word, San Antonio, TX, United States

Diabetic retinopathy is a microvascular disease of the retina, in which basal blood flow and the vascular responses to metabolic conditions in diabetic eyes are perturbed. To determine if diabetic mice have impaired retinal/choroidal blood flow and vascular reactivity, we measured ocular blood flow using MRI during hypercapnia. In diabetic mice, basal choroidal blood flow was significantly decreased. In both control and diabetic mice, hypercapnia caused a significant increase in retinal and choroidal blood flow, but the choroidal response was significantly reduced in diabetic mice, indicating impaired vascular reactivity.

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