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Abstract #3318

Parametric maps of murine cancers from dynamic contrast enhanced MRI: low versus high doses of contrast agent

Xiaobing Fan1, Xueyan Zhou2, Devkumar Mustafi1, Federico Pineda1, Erica Markiewicz1, Marta Zamora1, Deepa Sheth1, Olufunmilayo I. Olopade3, and Gregory S. Karczmar1
1Radiology, The University of Chicago, Chicago, IL, United States, 2School of Technology, Harbin University, Harbin, China, 3Medicine, The University of Chicago, Chicago, IL, United States

We compared dynamic contrast enhanced (DCE) MRI with low (0.04mmol/kg) and high doses (0.2mmol/kg) of contrast agent on C3H mice at 9.4T with 1.5s temporal resolution before and after a bolus injection. The standard Tofts model was used to extract physiological parameters (Ktrans and ve) with arterial input function derived from muscle reference tissue. On average, rate constants were larger for low dose than high dose data. There were strong correlations for Ktrans and ve between low and high dose data. Therefore, low dose may be as effective as a high dose of contrast agent for cancer diagnosis.

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