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Abstract #3319

Parameters From Dynamic Contrast-Enhanced MRI Are Biomarkers Predicting Response after Radiotherapy to Brain Metastases

Zhuo Shi1, Lizhi Xie2, Peng Wang1, Xinming Zhao1, and Han Ouyang1
1National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences, Beijing, China, 2GE Healthcare, MR Research China, Beijing, Beijing, China

Dynamic contrast-enhanced (DCE) MRI provides additional information on blood-brain barrier integrity. The Ktrans is a measure of capillary permeability obtained using DCE MRI that is directly proportional to the level of permeability of the blood-brain barrier. The purpose of this study was to evaluate the effect of SRS on cerebral metastases using Ktrans derived from DCE MRI and to explore the ability of Ktrans measurements on predicting midterm tumor outcomes after Stereotactic radiosurgery (SRS).

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