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Abstract #3322

Mechanical Property Recovery in the Cerebral Cortex using Magnetic Resonance Elastography

Lucy V Hiscox1, Matthew DJ McGarry2, and Curtis L Johnson1
1University of Delaware, Newark, DE, United States, 2Dartmouth College, Hanover, NH, United States

Magnetic resonance elastography of the brain has shown promise as a sensitive neuroimaging biomarker for neurodegenerative disorders; however, the feasibility and reliability of performing MRE of the cerebral cortex warrants investigation due to the unique challenges of studying thinner and more complex geometries. In this work, we found good agreement between realistic simulated MRE data versus recovered displacement data of an older adult participant at various levels of applied Gaussian noise. Future work should consider additional and more advanced imaging and inversion approaches to improve the reliability and sensitivity of cortical MRE measures.

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