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Abstract #3323

Robustness of MR Elastography in the brain – Test-retest reliability and effect of different reconstruction methods

Siri Flogstad Svensson1, Jorunn Fraser-Green2, Omar Darwish3, José Rodriguez de Arcos3, Tryggve Holck Storås1, Sverre Holm4, Ralph Sinkus3,5, and Kyrre Eeg Emblem1
1Department for Diagnostic Physics, Oslo University hospital, Oslo, Norway, 2The Intervention Center, Oslo University hospital, Oslo, Norway, 3Division of Imaging Sciences & Biomedical Engineering, King's College, London, United Kingdom, 4Department of Informatics, University of Oslo, Oslo, Norway, 5INSERM U1148, LVTS, University Paris Diderot, Paris, France

We assessed the test-retest reliability of MR Elastography, and compared the estimates of the shear storage modulus G’ (tissue elasticity) from two different reconstruction methods; a localized divergence-free finite-element approach and a local curl approach. The median coefficient of variation for two scans of the brain was 2.8 %, whereas the intraclass correlation coefficient between scan 1 and scan 2 was 0.80. G’ values estimated using the local curl method were 19% lower than with the divergence-free method. MRE of the human brain appears robust, while absolute values are dependent on the reconstruction method and should be used with care.

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