Abstract #3323

Robustness of MR Elastography in the brain – Test-retest reliability and effect of different reconstruction methods

Siri Flogstad Svensson¹, Jorunn Fraser-Green², Omar Darwish³, José Rodriguez de Arcos³, Tryggve Holck Storås¹, Sverre Holm⁴, Ralph Sinkus^3,5, and Kyrre Eeg Emblem¹

¹Department for Diagnostic Physics, Oslo University hospital, Oslo, Norway, ²The Intervention Center, Oslo University hospital, Oslo, Norway, ³Division of Imaging Sciences & Biomedical Engineering, King's College, London, United Kingdom, ⁴Department of Informatics, University of Oslo, Oslo, Norway, ⁵INSERM U1148, LVTS, University Paris Diderot, Paris, France

We assessed the test-retest reliability of MR Elastography, and compared the estimates of the shear storage modulus G’ (tissue elasticity) from two different reconstruction methods; a localized divergence-free finite-element approach and a local curl approach. The median coefficient of variation for two scans of the brain was 2.8 %, whereas the intraclass correlation coefficient between scan 1 and scan 2 was 0.80. G’ values estimated using the local curl method were 19% lower than with the divergence-free method. MRE of the human brain appears robust, while absolute values are dependent on the reconstruction method and should be used with care.

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