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Abstract #3324

Ultra-low frequency MR elastography of the in vivo human brain from endogenous pulsation to 40 Hz time-harmonic vibrations.

Helge Herthum1, Heiko Tzschätzsch1, Felix Schrank1, Mehrgan Shahryari1, Gergely Bertalan1, Carsten Warmuth1, Jürgen Braun2, and Ingolf Sack1
1Department of Radiology, Charité Universitätsmedizin Berlin, Berlin, Germany, 2Institute of Medical Informatics, Charité Universitätsmedizin Berlin, Berlin, Germany

In this work, we applied single-shot steady-state MR elastography with spiral readout for quantifying shear wave speed (SWS) from endogenous pulsation to 40 Hz external vibrations with high sampling rate for first-time measurement of SWS dispersion of in vivo human brain in the ultra-low frequency regime. Ground truth SWS was determined by profile fitting approaches and reproduced by SWS mapping based on frequency-adaptive multi-component wave-number inversion. The obtained SWS dispersion was fitted by two-parameter viscoelastic models showing that brain tissue is dominated by fluid properties in this ultra-low frequency regime. Our method is potentially sensitive to vessel-related neurological disorders.

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