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Abstract #3325

Development of in vivo human brain DTI-MRE

Shujun Lin1, Brad Sutton2, Richard Magin1, and Dieter Klatt1
1Richard and Loan Hill Department of Bioengineering, University of Illinois at Chicago, Chicago, IL, United States, 2Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana-Champaign, IL, United States

Simultaneous acquisition of diffusion tensor imaging (DTI) and magnetic resonance elastography (MRE) has been proven feasible in previous pre-clinical studies. DTI-MRE requires the identification of experimental parameter ranges that depend on the specific target. Here we identify valid experimental parameter sets in simulations for in vivo human brain applications and the DTI-MRE technique is implemented by modifying a single-shot spin-echo EPI sequence. A good agreement was found between DTI-MRE and conventional acquisitions. DTI-MRE may increase the clinical acceptance of MRE and DTI by providing co-registered diffusion and tissue mechanical property maps within the scan time of a conventional DTI acquisition.

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