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Abstract #3326

The Investigation of Three-Dimensional MR elastography of the Brain in Multiple Sclerosis

Ling Fang1, Matthew C. Murphy2, Sujuan Liu1, Qiuxia Luo1, Jingbiao Chen1, Bingjun He1, Wei Qiu3, Jun Chen2, Meng Yin2, Kevin J. Glaser2, Richard L. Ehman2, and Jin Wang1
1Department of Radiology, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China, 2Department of Radiology, Mayo Clinic, Rochester, MN, United States, 3Department of Neurology, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China

Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system. MR Elastography (MRE) can quantitatively measure biomechanical tissue properties in vivo noninvasively. In this study, we investigated the potential value of MRE for the evaluation of centrum ovale viscoelasticity (including shear stiffness, storage modulus, shear loss modulus, and damping ratio) in Southern Chinese MS patients and to try to analyze its relevance to clinical manifestations. Our results showed that only the damping ratio of the centrum ovale was significantly decreased in MS patients and may provide a potential quantitative biomarker to evaluate MS.

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