Interstitial lung diseases alter the mechanical properties of the lung parenchyma. Lung stiffness is a potential diagnostic marker. Standard breath hold techniques are difficult for patient with pulmonary disease. By using a free breathing Spin-Echo Dual-Density Spiral (SE-DDS) MRE sequence, a feasibility study was performed on 6 idiopathic pulmonary fibrosis (IPF) patients. It was found that the shear stiffness of IPF diseased lung is 2±0.48kPa for the right lung and 1.99±0.42kPa for the left lung which is significantly higher (P=0.0108 and P=0.0072) than healthy lungs, which has shear stiffness of 1.29±0.35kPa and 1.43±0.16kPa for right and left lungs, respectively.
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