Abstract #3334

Validation of the Accuracy of Magnetic Resonance Elastography of the Liver via 3D Finite Element Modelling Simulation

Deirdre McGrath^1,2, Christopher Bradley^1,2, and Susan Francis^1,2

¹NIHR Nottingham Biomedical Research Centre, Radiological Sciences, Division of Clinical Neuroscience, Queens Medical Centre, Nottingham, United Kingdom, ²Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom

In this novel study, magnetic resonance elastography (MRE) of the liver is simulated in a detailed 3D anthropomorphic finite element model of the human torso, to explore the influence of imaging spatial resolution and motion-based signal to noise ratio (SNR) on the accuracy of elastograms calculated by direct inversion. It was found that MRE accuracy was highly dependent on imaging voxel dimensions, motion-SNR and the ground truth material properties. These findings will guide the optimisation and development of future liver MRE methodology.

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