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Abstract #3335

Tomoelastography for Quantification of Heterogeneity in Primary Sclerosing Cholangitis-related Hepatic Fibrosis

Rolf Reiter1,2, Heiko Tzschätzsch1, Matthias Haas1, Christian Bayerl1, Dieter Klatt2, Meltem Uyanik2, Shreyan Majumdar2, Marion Muche3, Bernd Hamm1, Jürgen Braun4, Ingolf Sack1, and Patrick Asbach1
1Radiology, Charité - Universitätsmedizin Berlin, Berlin, Germany, 2Bioengineering, University of Illinois at Chicago, Chicago, IL, United States, 3Hepatology, Charité - Universitätsmedizin Berlin, Berlin, Germany, 4Medical Informatics, Charité - Universitätsmedizin Berlin, Berlin, Germany

Primary sclerosing cholangitis (PSC) is a rare chronic liver disease that leads to stricturing of bile ducts and a heterogeneous distribution of hepatic fibrosis. Despite the success of MR cholangiopancreaticogram and liver biopsy for the detection of PSC, they do not correlate with the severity of disease. Currently, there is no accurate diagnostic reference standard for monitoring the disease activity in PSC which limits patient management. Tomoelastography has the potential to quantify heterogeneity in PSC-related hepatic fibrosis using a normalized standard deviation index as a new biomarker besides overall stiffness.

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