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Abstract #3362

The impact of through-plane motion on 2D FISP-MR Fingerprinting: a simulation study based on realistic patient and healthy volunteer movements

Pedro Lima Cardoso1, Gregor Körzdörfer2, Eva Hečková1, Mathias Nittka2, Siegfried Trattnig1,3, and Wolfgang Bogner1,3
1High Field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, 2Siemens Healthcare GmbH, Erlangen, Germany, 3Christian Doppler Laboratory for Clinical Molecular MR Imaging, MOLIMA, Vienna, Austria

Motion-induced artifacts in quantitative MRI may not be visually detectable. MRF has shown to be robust to in-plane movement, and methods to mitigate it were made available. However, the impact of clinically prevalent motion patterns has not yet been investigated. The effect of realistic motion data from patients with neurodegenerative disorders and young/elderly controls on 2D FISP-MRF is therefore investigated in this simulation study. Results are validated with in-vivo motion-tracked measurements. Although through-plane motions were shown to significantly impact MRF parametric maps (particularly T2), MRF may preserve its sensitivity in clinical cases in which expected lesion-related differences are large enough.

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