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Abstract #3445

A rapid quantitative Multi-inversion SAGE-EPI brain protocol with subspace reconstruction and navigation-free shot-to-shot phase correction  

Mary Kate Manhard1,2, Zijing Dong1,3, Congyu Liao1,2, Merlin Fair1,2, Fuyixue Wang1,4, Berkin Bilgic1,2, and Kawin Setsompop1,2,4
1A.A. Martinos Center for Biomedical Imaging, Boston, MA, United States, 2Department of Radiology, Harvard Medical School, Boston, MA, United States, 3Department of Electrical Engineering and Computer Science, Massachusetts Institution of Technology, Cambridge, MA, United States, 4Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA, United States

Recently, multi-contrast EPI approaches have been proposed for a fast screening brain protocol. With EPI-encoding, multiple contrasts can be acquired quickly for robust, quantitative mapping as well as creation of synthetic weighted images. Here, a spatiotemporal subspace reconstruction is developed to jointly reconstruct multi-contrast multishot-EPI data from a multi-inversion Spin and Gradient echo EPI (MI-SAGE-EPI) acquisition. An approach to estimate and incorporate shot-to-shot phase corruption into the reconstruction was also developed. This navigation-free subspace reconstruction achieves good reconstruction for MI-SAGE-EPI at a high EPI-acceleration, thus enabling a rapid quantitative protocol at high in-plane resolution with minimal distortion and blurring.

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