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Abstract #3461

Quantitative comparison of a brain protocol with and without FRONSAC enhancement

E. H. Bhuiyan1, Y. Rodriguez1, R. Todd Constable1, and G. Galiana1
1Radiology and Biomedical Imaging, Yale University, New Haven, CT, United States

FRONSAC has previously been demonstrated as a highly effective approach to using nonlinear gradients to reduce undersampling artifacts, but previous results were limited to proof-of-principle experiments in individual subjects. Here we report quantitative comparisons for a full protocol of standard brain imaging sequences (2D GRE, 2D TSE, 2D T2w-FLAIR, 3D GRE and 3D MP-RAGE) acquired in a cohort of healthy subjects, comparing standard Cartesian to FRONSAC-enhanced acquisitions. Preliminary results confirm that FRONSAC significantly improves undersampling artifacts, measured as RMSE relative to a fully sampled Cartesian reference, while retaining the contrast, SNR, and reliability of standard Cartesian sequences.

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