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Abstract #3660

Measures of lesion load on white matter fiber bundles for damage assessment

Guillem Garcia1, David Moreno-Dominguez1, Marc Ramos 1, and Matt Rowe1
1Medical Imaging, QMENTA Inc., Boston, MA, United States

Measures of lesion load are useful to study how damage in the white matter present in different pathologies relate to changes in cognitive function. So far, most research focus on global or local volumetric metrics, an approach that exhibits limitations in cases where small lesions in specific places cause major damages. In this work, we propose the combined use of a set of metrics that measure different aspects of the lesions over the major white matter bundles. We expose how these metrics provide complementary information, and discuss how its usefulness could be assessed in future work.

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