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Abstract #3730

A multi echo pulse sequence with optimized excitation pulses and a 3D cone readout for hyperpolarized 13C imaging

Vencel Somai1,2, Alan J Wright1, Maria Fala1, Friederike Hesse1, and Kevin M Brindle1,3
1Cancer Research UK Cambridge Institute, Cambridge, United Kingdom, 2Department of Radiology, University of Cambridge, Cambridge, United Kingdom, 3Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom

We describe here a single shot multi echo sequence for dynamic hyperpolarized 13C imaging with a short readout time, isotropic point spread function (PSF) and high immunity to B0 and B1 field inhomogeneity. The sequence uses numerically optimized excitation pulses and a 3D cone k-space trajectory composed of 13 cones, all fully refocused and distributed among 7 spin echoes. The maximal gradient amplitude and slew-rate were set to 4 G/cm and 20 G/cm/ms respectively to demonstrate the feasibility of clinical translation. The sequence was demonstrated with dynamic imaging of hyperpolarized [1-13pyruvate] and [1-13C]lactate in vivo.

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