Abstract #3730

A multi echo pulse sequence with optimized excitation pulses and a 3D cone readout for hyperpolarized 13C imaging

Vencel Somai^1,2, Alan J Wright¹, Maria Fala¹, Friederike Hesse¹, and Kevin M Brindle^1,3

¹Cancer Research UK Cambridge Institute, Cambridge, United Kingdom, ²Department of Radiology, University of Cambridge, Cambridge, United Kingdom, ³Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom

We describe here a single shot multi echo sequence for dynamic hyperpolarized ¹³C imaging with a short readout time, isotropic point spread function (PSF) and high immunity to B₀ and B₁ field inhomogeneity. The sequence uses numerically optimized excitation pulses and a 3D cone k-space trajectory composed of 13 cones, all fully refocused and distributed among 7 spin echoes. The maximal gradient amplitude and slew-rate were set to 4 G/cm and 20 G/cm/ms respectively to demonstrate the feasibility of clinical translation. The sequence was demonstrated with dynamic imaging of hyperpolarized [1-¹³pyruvate] and [1-¹³C]lactate in vivo.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.