Abstract #3731

Highly Accelerated EPI with Wave Encoding and Multi-shot Simultaneous MultiSlice Imaging

Jaejin Cho^1,2, Congyu Liao^1,2, Zijing Zhang^1,3, Wei-Ching Lo⁴, Jinmin Xu^1,3, Onur Beker^1,5, Kawin Setsompop^1,2,6, and Berkin Bilgic^1,2,6

¹Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States, ²Harvard Medical School, Boston, MA, United States, ³College of Optical Science and Engineering, Zhejiang University, Hangzhou, China, ⁴Siemens Medical Solution, Boston, MA, United States, ⁵Electrical and Electronics Engineering, Bogazici University, Istanbul, Turkey, ⁶Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA, United States

We combine wave controlled aliasing strategy with echo-planar imaging (EPI) and simultaneous multi-slice (SMS) encoding to increase acquisition efficiency and reduce geometric distortion simultaneously for functional (fMRI) and diffusion (dMRI) imaging. Wave-EPI enables R_inxR_sms=4x3-fold accelerated single-shot gradient-echo (GE)-EPI by reducing the maximum g-factor noise amplification by 2-fold compared to blip-CAIPI. We extend wave-EPI to multi-shot acquisition and incorporate Hankel low-rank constraint to leverage the similarities among the shots for improved reconstruction. This allows us to create a 10-second structural scan with 12-fold reduced distortion and push the acceleration rate to R_inxR_sms=6x3-fold in dMRI using 3-shots with markedly improved image quality.

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