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Abstract #3731

Highly Accelerated EPI with Wave Encoding and Multi-shot Simultaneous MultiSlice Imaging

Jaejin Cho1,2, Congyu Liao1,2, Zijing Zhang1,3, Wei-Ching Lo4, Jinmin Xu1,3, Onur Beker1,5, Kawin Setsompop1,2,6, and Berkin Bilgic1,2,6
1Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States, 2Harvard Medical School, Boston, MA, United States, 3College of Optical Science and Engineering, Zhejiang University, Hangzhou, China, 4Siemens Medical Solution, Boston, MA, United States, 5Electrical and Electronics Engineering, Bogazici University, Istanbul, Turkey, 6Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA, United States

We combine wave controlled aliasing strategy with echo-planar imaging (EPI) and simultaneous multi-slice (SMS) encoding to increase acquisition efficiency and reduce geometric distortion simultaneously for functional (fMRI) and diffusion (dMRI) imaging. Wave-EPI enables RinxRsms=4x3-fold accelerated single-shot gradient-echo (GE)-EPI by reducing the maximum g-factor noise amplification by 2-fold compared to blip-CAIPI. We extend wave-EPI to multi-shot acquisition and incorporate Hankel low-rank constraint to leverage the similarities among the shots for improved reconstruction. This allows us to create a 10-second structural scan with 12-fold reduced distortion and push the acceleration rate to RinxRsms=6x3-fold in dMRI using 3-shots with markedly improved image quality.

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