Abstract #3755

The effect of hormone therapy on T1 mapping-related values obtained from MR fingerprinting-derived images of prostate cancer patients

Nikita Sushentsev¹, Joshua D Kaggie¹, Guido Buonincontri^2,3, Rolf Schulte⁴, Vincent J Gnanapragasam^5,6,7, Martin J Graves¹, and Tristan Barrett^1,8

¹Department of Radiology, University of Cambridge, Cambridge, United Kingdom, ²IRCCS Stella Maris, Piza, Italy, ³Imago7 Foundation, Piza, Italy, ⁴GE Healthcare, Munich, Germany, ⁵6) Cambridge Urology Translational Research and Clinical Trials Office, University of Cambridge, Cambridge, United Kingdom, ⁶Academic Urology Group, Department of Surgery & Oncology, University of Cambridge, Cambridge, United Kingdom, ⁷Department of Urology, University of Cambridge, Cambridge, United Kingdom, ⁸2) CamPARI Prostate Cancer Group, Addenbrooke's Hospital, Cambridge, United Kingdom

This study investigates the effect of hormone therapy for prostate cancer on T1 mapping values obtained from MR Fingerprinting. No differences were observed between tumour T1 values before and after treatment. However, lower T1 MRF values were noted in prostate lesions compared to normal peripheral and transition zones, which is consistent with current literature. Moreover, a significant decrease in T1 values was observed in normal transition zone (TZ) following treatment, which may justify the need of using T1 mapping in contrast-enhanced MRI studies aimed at calculating quantitative TZ-derived parameters.

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