Abstract #3771

Blood Flow and Permeability Imaging in a Rat Stroke Model Using 3D Compressed-Sensing DCE-MRI

Radovan Jiřík¹, Lucie Krátká¹, Jiří Kratochvíla¹, Ondřej Macíček¹, Ye Tian², Peter Scheer³, Jana Hložková³, Edward DiBella², and Zenon Starčuk, jr.¹

¹Institute of Scientific Instruments of the CAS, Brno, Czech Republic, ²Utah Center for Advanced Imaging and Research, University of Utah, Salt Lake City, UT, United States, ³University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic

The main challenge of using DCE-MRI in stroke in combination with advanced pharmacokinetic models is the need for high temporal resolution, whole-brain coverage and a low SNR (especially in small-animal MRI) of the DCE signal (compared to DSC, due to the BBB and low fractional blood volume in brain). In this pilot study we test if compressed sensing could help solve these challenges.

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