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Abstract #3771

Blood Flow and Permeability Imaging in a Rat Stroke Model Using 3D Compressed-Sensing DCE-MRI

Radovan Jiřík1, Lucie Krátká1, Jiří Kratochvíla1, Ondřej Macíček1, Ye Tian2, Peter Scheer3, Jana Hložková3, Edward DiBella2, and Zenon Starčuk, jr.1
1Institute of Scientific Instruments of the CAS, Brno, Czech Republic, 2Utah Center for Advanced Imaging and Research, University of Utah, Salt Lake City, UT, United States, 3University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic

The main challenge of using DCE-MRI in stroke in combination with advanced pharmacokinetic models is the need for high temporal resolution, whole-brain coverage and a low SNR (especially in small-animal MRI) of the DCE signal (compared to DSC, due to the BBB and low fractional blood volume in brain). In this pilot study we test if compressed sensing could help solve these challenges.

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