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Abstract #3770

Three-Dimensional Free-breathing Whole-Liver Simultaneous T1, R2*, and Fat-Fraction Quantification Using MR Multitasking

Nan Wang1,2, Anthony G Christodoulou1, Yibin Xie1, Fei Han3, Xiaodong Zhong3, Sen Ma1,2, Xiaoming Bi3, Vibhas Deshpande4, and Debiao Li1
1Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, 2Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States, 3Siemens Healthcare, Los Angeles, CA, United States, 4Siemens Healthcare, Austin, TX, United States

Quantitative MRI has been playing a key role in the assessment and characterization of liver. However, current applications are still facing technical challenges. In this work, we proposed a novel technique based on MR Multitasking, which enables simultaneous T1, R2*, and FF quantification in one scan with free-breathing acquisition, 3D whole-liver coverage, and sufficient spatial resolution. The feasibility of the proposed method were demonstrated on the volunteer study (N = 8), showing that the T1, R2*, and FF quantification was repeatable in vivo and consistent with the results from the reference methods.

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