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Abstract #3783

In Vivo Validation of MRS- and MRI-Based Fatty Acid Composition Quantification against Gas Chromatography in Adipose Tissue

Lena Trinh1, Pernilla Peterson1,2, Håkan Brorson3, and Sven Månsson1,4
1Medical Radiation Physics, Department of Translational Medicine, Lund University, Malmö, Sweden, 2Medical Imaging and Physiology, Skåne University Hospital, Lund, Sweden, 3Department of Plastic and Reconstructive Surgery, Skåne University Hospital, Malmö, Sweden, 4Radiation Physics, Skåne University Hospital, Malmö, Sweden

Non-invasive estimation of the fatty acid composition of adipose tissue using MRI or MRS may be valuable in a number of disease scenarios. However, in vivo validation against an independent gold standard is still needed. In this work, we find that especially MRI estimation of the fraction of saturated fatty acids is strongly associated to gas chromatography analysis in the adipose tissue of lymphedema patients. The reliability of the estimated mono- and polyunsaturated fractions are reliant on the used signal model. Also MRS provided results which are associated to GC analysis, but with a lower agreement compared to MRI.

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