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Abstract #3786

Towards robust QSM in cortical and sub-cortical regions of the human brain at 9.4T: influence of coil combination and masking strategies

Gisela E Hagberg1,2, Korbinian Eckstein3, Enrique Cuna4, Simon Robinson3,5, and Klaus Scheffler1,2
1Biomedical Magnetic Resonance, University Hospital Tübingen, Tübingen, Germany, 2High Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Tübingen, Germany, 3High Field MR Centre, Medical University of Vienna, Vienna, Austria, 4Centro Uruguayo de Imagenología Molecular (CUDIM), Montevideo, Uruguay, 5Centre for Advanced Imaging, University of Queensland, Brisbane, Australia

Strong background signals leading to multiple phase wraps may hamper accurate quantification of magnetic tissue susceptibility (QSM) especially at high field strengths using long echo times to achieve a high spatial sampling. Here we show how different coil-combination, automated tissue masking and background removal techniques can be used to improve QSM quality. Performance was evaluated with regard to iron quantification in subcortical and cortical areas in the same subjects. We found a substantial improvement in accuracy and precision of QSM in high-field applications at long echo times through the use of ASPIRE and removal of areas with excessive phase evolution.

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