Abstract #3788

To Evaluate the Effect of Compressed-SENSE on Accuracy of High-Resolution Quantitative T1-Perfusion MRI Parameters and on glioma grading at 3T

Dinil Sasi S¹, Rakesh K Gupta², Indrajit Saha³, Anandh K Ramaniharan³, and Anup Singh^4,5

¹Indian Institute of Technology Delhi, New Delhi, India, ²Fortis Memorial Research Institute, Gurugram, India, ³Philips India Limited, Gurugram, India, ⁴Indian Institute of Technology Delhi, Hauz Khas, India, ⁵All India Institute of Medical Science, New Delhi, India

T1-perfusion derived parameters have been utilized for brain tumor quantification and grading. In this study, we have analyzed the potential of Compressed SENSE (CSENSE) acceleration technique on high resolution T1-perfusion MRI for quantitative analysis of brain tumor(glioma) and compared its performance and accuracy with conventional acquisition protocol in terms of concentration-time curve, perfusion parameters and glioma grading. A prospective analysis was also carried on healthy subjects to analyze the spatial error propagation at different acceleration factors(R). All derived perfusion parameters were able to quantify and differentiate different tumor classes with improved concentration-time curve(High grade and low grade glioma).

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