Three-dimensional variable-flip-angle(VFA) T1-mapping is a rapid T1 quantification method with important clinical applications. However, the requirement of acquiring multiple 3D images greatly increases the scan time. We propose a novel application of SUPER—a recently developed framework for parametric mapping acceleration—to reduce scan time and/or improve spatial resolution of 3D VFA T1-mapping. In healthy subjects, we demonstrate that SUPER(R=2) and SUPER-SENSE(R=4 combining SUPER and parallel imaging) achieved similar accuracy, reasonable noise amplification, and similar reconstruction time compared with the non-acceleration gold standard. The whole upper-brain T1-mapping scan time was reduced from 5.33 minutes to 1.33 by employment of SUPER-SENSE.