Abstract #3792

Brain T1 relaxometry changes across the life span: a comparison between two populations

Gian Franco Piredda^1,2,3, Peipeng Liang⁴, Tom Hilbert^1,2,3, Karl Egger⁵, Shan Yang⁵, Jean-Philippe Thiran^2,3, Bénédicte Maréchal^1,2,3, Yi Sun⁶, Kuncheng Li^7,8, and Tobias Kober^1,2,3

¹Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, ²Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland, ³LTS5, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, ⁴School of Psychology, Capital Normal University, Beijing Key Laboratory of Learning and Cognition, Beijing, China, ⁵Faculty of Medicine, University of Freiburg, Freiburg, Germany, ⁶MR Collaboration, Siemens Healthcare Ltd., Shanghai, China, ⁷Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, China, ⁸Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, China

Understanding the normal evolution of T₁ values across the life span allows to disentangle ageing from degenerative pathologies. Following previous studies reporting brain anatomical and functional differences between Western and Chinese cohorts, this work investigates whether differences in the evolution of T₁ values across the life span exist between these two populations using two datasets with 200 healthy subjects each. Derived trends were found to differ between the two populations in some brain structures, especially in grey matter tissues. The observed differences may indicate that norms derived from one population may not be directly applied to another without recalibration.

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