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Abstract #3792

Brain T1 relaxometry changes across the life span: a comparison between two populations

Gian Franco Piredda1,2,3, Peipeng Liang4, Tom Hilbert1,2,3, Karl Egger5, Shan Yang5, Jean-Philippe Thiran2,3, Bénédicte Maréchal1,2,3, Yi Sun6, Kuncheng Li7,8, and Tobias Kober1,2,3
1Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, 2Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland, 3LTS5, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, 4School of Psychology, Capital Normal University, Beijing Key Laboratory of Learning and Cognition, Beijing, China, 5Faculty of Medicine, University of Freiburg, Freiburg, Germany, 6MR Collaboration, Siemens Healthcare Ltd., Shanghai, China, 7Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, China, 8Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, China

Understanding the normal evolution of T1 values across the life span allows to disentangle ageing from degenerative pathologies. Following previous studies reporting brain anatomical and functional differences between Western and Chinese cohorts, this work investigates whether differences in the evolution of T1 values across the life span exist between these two populations using two datasets with 200 healthy subjects each. Derived trends were found to differ between the two populations in some brain structures, especially in grey matter tissues. The observed differences may indicate that norms derived from one population may not be directly applied to another without recalibration.

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