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Abstract #3794

Quantitative T2 Mapping using Accelerated 3D Stack-of-Spiral GRE Acquisition

Ruoxun Zi1, Dan Zhu1,2, Wenbo Li2,3, and Qin Qin2,3
1Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 3F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

We presented a T2 prepared stack-of-spiral gradient echo (GRE) pulse sequence with or without CSF nulling for T2 mapping of brain. T2 maps were iteratively optimized by data consistency, model consistency and spatial sparsity regularization using projected-gradients approach, which was evaluated by in vivo experiments and compared with SENSE, CS SENSE and model-based methods. The proposed reconstruction method provided better performance with normalized root mean square error (nRMSE) of the whole brain T2 estimation equal to 8.2±0.5% with an acceleration factor of 5. The T2 estimation with and without CSF nulling were consistent.

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