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Abstract #3799

Optimization of Keyhole Imaging Parameters for Glutamate Chemical Exchange Saturation Transfer (GluCEST) MRI at 7.0 T

Dong-Hoon Lee1, Do-Wan Lee2, Chul-Woong Woo3, Hwon Heo4, Jae-Im Kwon3, Yeon Ji Chae4, Su Jung Ham5, Jeong Kon Kim2, Kyung Won Kim2,5, and Dong-Cheol Woo3,4
1Faculty of Health Sciences and Brain & Mind Centre, The University of Sydney, Sydney, Australia, 2Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea, 3Convergence Medicine Research Center, Asan Institute for Life Sciences, Asan Medical Center, Seoul, Republic of Korea, 4Department of Convergence Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea, 5Asan Image Research, Asan Institute for Life Sciences, Asan Medical Center, Seoul, Republic of Korea

We evaluated the effects of a reference image and keyhole factor selections for high-frequency substitution on a keyhole imaging technique for application in glutamate CEST (GluCEST) imaging to reduce data acquisition time. The calculated GluCEST signals and visually inspected results from the reconstructed GluCEST maps indicated that a combination of unsaturated image as a reference image and >50% of keyhole factors showed consistent signals and image quality as opposed to the fully-sampled CEST data. Combining the keyhole imaging technique with GluCEST imaging enables stable image reconstruction and quantitative evaluation, and this approach is potentially implemented in various CEST imaging applications.

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