Abstract #3816

Disentangling hippocampal perfusion from the macrovasculature using ASL and TOF at 7T

Roy AM Haast¹, Sriranga Kashyap², Jordan DeKraker¹, Dimo Ivanov², Benedikt A Poser², and Ali R Khan^1,3

¹Robarts Research Institute, Western University, London, ON, Canada, ²Department of Cognitive Neuroscience, Maastricht University, Maastricht, Netherlands, ³Department of Medical Biophysics, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada

Arterial spin labeling (ASL) at 7T can be used to map cerebral blood flow (CBF) at a high spatial resolution. Previously, we have shown that different hippocampal subfields have differences in perfusion, owing to potential differences in their vascular density. Hippocampal imaging at 7T can be challenging and requires optimizations of acquisition methods, as well as integration of novel analysis strategies. Here, we map high-resolution quantitative multi-modal MRI data (T₁, CBF, time-of-flight angiography) in the human hippocampus to disentangle perfusion and macrovasculature at 7T.

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