Abstract #3817

Whole-Brain Functional MRI in Human Subjects Wearing Metallic Orthodontic Braces

Xinyuan Miao^1,2, Yuankui Wu^1,2,3, Dapeng Liu^1,2, Qin Qin^1,2, Peter C.M van Zijl^1,2, Jay J. Pillai^4,5, and Jun Hua^1,2

¹Neurosection, Division of MRI Research, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ³Department of Medical Imaging, Nanfang Hospital, Southern Medical University, Guangzhou, China, ⁴Johns Hopkins University School of Medicine, Division of Neuroradiology, Russell H. Morgan Department of Radiology and Radiological Science, Baltimore, MD, United States, ⁵Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Metallic objects such as dental braces bring substantial susceptibility artifacts in MR images acquired using echo-planar-imaging (EPI) sequences. Gradient-echo EPI is currently the most commonly adopted sequence for blood oxygenation level–dependent (BOLD) functional MRI (fMRI) in humans, which suffers from susceptibility artifacts including signal dropout and geometric distortion in the presence of metallic implants. Here, we demonstrate that T2-prepared (T2prep) BOLD fMRI can significantly reduce susceptibility artifacts that are commonly seen in GRE EPI in the presence of metallic orthodontic braces.

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