The purpose of this study is to develop a multi-contrast, multi-echo sequence using spin- and gradient-echo (SAGE) for fMRI; furthermore, we sought to assess various analysis schemes for optimal quantification of fMRI. For this purpose, we acquired SAGE-fMRI data with five echoes (2 gradient-echo, 2 asymmetric spin-echoes, and 1 spin-echo) using a visual stimuli task in 8 healthy subjects. Analysis was performed using each echo signal individually, using weighting factors to combine dynamic signals, and by quantifying dynamic R2* and R2 time-courses. These methods are compared to determine the optimal analysis method for SAGE-fMRI.
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