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Abstract #3822

Optimization of vascular and functional sensitivity using multi-contrast, multi-echo SAGE-EPI for fMRI

Maurizio Bergamino1, Lori Steffes1, Ashlyn Gonzales2, Leslie Baxter2, and Ashley M. Stokes1
1Neuroimaging Research, Barrow Neurological Institute, Phoenix, AZ, United States, 2Neuropsychology, Mayo Clinic Arizona, Phoenix, AZ, United States

The purpose of this study is to develop a multi-contrast, multi-echo sequence using spin- and gradient-echo (SAGE) for fMRI; furthermore, we sought to assess various analysis schemes for optimal quantification of fMRI. For this purpose, we acquired SAGE-fMRI data with five echoes (2 gradient-echo, 2 asymmetric spin-echoes, and 1 spin-echo) using a visual stimuli task in 8 healthy subjects. Analysis was performed using each echo signal individually, using weighting factors to combine dynamic signals, and by quantifying dynamic R2* and R2 time-courses. These methods are compared to determine the optimal analysis method for SAGE-fMRI.

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