Abstract #3826

Apparent attenuation of BOLD macro-vascular contributions with high-frequency stimuli

Daniel E. P. Gomez^1,2,3, Nina E. Fultz^1,3, Shahin Nasr^1,2, Jonathan R. Polimeni^1,2,4, and Laura D. Lewis^1,3

¹Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, United States, ²Department of Radiology, Harvard Medical School, Boston, MA, United States, ³Department of Biomedical Engineering, Boston University, Boston, MA, United States, ⁴Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology, Boston, MA, United States

Fast fMRI signals may reflect an enhanced relative contribution of fast microvascular signals in the BOLD response. In the current work we tested whether using fast oscillatory stimulus frequencies indeed leads to a relative attenuation of the signal from draining veins, as compared to the microvasculature. Our results suggest that the relative contribution of deep BOLD signals is enhanced at high stimulus frequencies.

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