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Abstract #3827

Locally reduced cerebral blood flow in patients with Idiopathic Pulmonary Fibrosis

Kirsty Hett1, Eleonora Patitucci1, Hannah Chandler1, Michael Germuska1, Benjamin Hope-Gill2, and Richard Wise1,3
1Cardiff University Brain Research Imaging Centre (CUBRIC), Cardiff University, Cardiff, United Kingdom, 2Respiratory Medicine, Cardiff and Vale University Health Board, Cardiff, United Kingdom, 3Institute for Advanced Biomedical Technologies, Department of Neuroscience, Imaging and Clinical Sciences, "G. D'Annunzio University" of Chieti-Pescara, Chieti, Italy

Idiopathic Pulmonary Fibrosis (IPF) is a palliative lung condition. Neuroimaging has the potential to shed light on the neural pathways of cough, a common, troublesome symptom in IPF. However, given the nature of the condition, it is important to first understand the physiological state of brain tissue before investigating functional networks. No significant differences in brain volume were observed in IPF patients but a localised reduction in resting perfusion was seen. There was no difference in functional response when performing a combined motor and visual task. The results support future neuroimaging investigation into the cough pathway in IPF.

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