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Abstract #3849

Neural Basis of Global Resting-state ASL Perfusion Signals

Shichun Chen1, Wenna Duan1, Li Zhao2, David C. Alsop2, Wenming Luh3, and Weiying Dai1
1Computer Science, State University of New York at Binghamton, Binghamton, NY, United States, 2Radiology, Beth Israel Deaconess Medical Center & Harvard Medical School, Boston, MA, United States, 3National Institute on Aging, National Institite of Health, Baltimore, MD, United States

Global fluctuations of arterial spin labeling (ASL) signals may emerge from global synchronization of resting-state brain networks. We aimed to investigate the synchrony of ASL global signal with brain neural activity using simultaneously recorded ASL perfusion images and EEG. The correlation between the EEG frequency power time series and ASL global time courses was evaluated. The shape for time course of the correlation is very similar to hemodynamic response functional curve. The peak correlation time indicates that the global ASL signals follow the neural activity and the function of human brain is organized by the presence of global functional synchronization.

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