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Abstract #3850

Mouse BOLD fMRI of innocuous and putative noxious forepaw stimulation without cardiovascular modulation

Won Beom Jung1,2, Hyun-Ji Beom Shim1,3, and Seong-Gi Kim1,2
1Cener for Neuroscience Imaging Research (CNIR), Institute for Basic Science (IBS), Suwon-si, Gyeonggi-do, Korea, Republic of, 2Department of Biomedical Engineering, Sungkyunkwan University, Suwon-si, Gyeonggi-do, Korea, Republic of, 3Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences and Technology (SAIHST), Sungkyunkwan University, Suwon-si, Gyeonggi-do, Korea, Republic of

The wide-spread and/or bilateral activity patterns in cortical and thalamic areas were common observation in response to innocuous and noxious electrical stimulation in mouse BOLD fMRI studies. Those findings may be related to the global BOLD effect confounded by stimulus-induced changes in cardiac functions such as heart rate and blood pressure, rather than originated from underlying neural activity. Under the ketamine-xylazine anesthesia, sympathetic activity is known to be suppressed. Here, we measured the response specificity of the BOLD signal responding from innocuous to putative noxious stimuli in mice under ketamine-xylazine anesthesia.

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