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Abstract #3852

BOLD Responses in the Rat Auditory Pathway Upon the Cessation of Sound

Frederico Severo1, Alfonso Renart1, and Noam Shemesh1
1Champalimaud Research, Champalimaud Centre for the Unknown, Lisboa, Portugal

Auditory offset responses due to cessation of auditory stimuli have been previously described, suggesting the existence of a dedicated auditory offset pathway. These responses are of major importance in auditory perception, as temporal cues like sound duration can be crucial for sound identification and interpretation. Still, studies on the subject are scarce compared to classic auditory onset responses. Here, we investigate the BOLD dynamics upon the cessation of sound using BOLD fMRI in the rat. We find differences between Onset and Offset paradigms suggesting negative BOLD responses observed in the latter are likely due to an active process.

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