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Abstract #3853

Effects of mild hypoxia on oxygen extraction fraction responses to brain stimulation

Yayan Yin1, Lang Qin2, and Jie Lu1
1Radiology, Capital Medical University, Beijing, China, 2Linguistics, the University of Hong Kong, Beijing, China

The oxygen extraction fraction (OEF) is a key physiological marker of cerebral oxygen metabolism. While the availability of oxygen plays a crucial role in oxygen metabolism, the effect of mild hypoxia on OEF during brain activity remains largely unclear. In this study, a novel OEF dynamic measurement technique, multiecho asymmetric spin echo pulse sequence, was used to investigate the OEF response during motor task in both normoxia and mild hypoxia. Results demonstrated that the motor-induced OEF response change was larger in mild hypoxia (-23% ± 6%) than that in normoxia (-12% ± 4%) and was positively correlated with oxygen saturation.

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