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Abstract #3863

Detection of Cortical Depth-dependent Functional Activation using Whole-brain, Half-millimetre Resolution EPIK at 7T

Seong Dae Yun1, Patricia Pais-Roldán1, and N. Jon Shah1,2,3,4
1Institute of Neuroscience and Medicine 4, INM-4, Forschungszentrum Juelich, Juelich, Germany, 2Institute of Neuroscience and Medicine 11, INM-11, Forschungszentrum Juelich, Juelich, Germany, 3JARA - BRAIN - Translational Medicine, Aachen, Germany, 4Department of Neurology, RWTH Aachen University, Aachen, Germany

The steady development of fMRI techniques has enabled the use of submillimetre-resolution in recent fMRI studies. The use of submillimetre-resolution allows the detection of cortical, depth-dependent brain activation. Although there have been numerous attempts to perform submillimetre-resolution fMRI, the level of spatial resolution in several recent works is still around 0.7 mm. Moreover, most methods do not provide whole-brain coverage. Therefore, this work aims to develop a novel half-millimetre resolution fMRI technique capable of providing whole-brain coverage. Here, the method was employed for exemplary finger-tapping fMRI at 7T and the identification of cortical-depth dependent brain activation was demonstrated.

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