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Abstract #3864

Beyond the limits of layer-dependent CBV fMRI in humans: strategies towards whole brain coverage, sub-second TR, and very high 0.5mm resolutions

Laurentius Huber1, Yuhui Chai2, Rüdiger Stirnberg3, Sriranga Kashyap1, Deni Kurban1, Arman Khojandi2, Dimo Ivanov1, Sean Marrett2, Tony Stöcker3,4, Kamil Uludag5, Peter Bandettini2, and Benedikt Poser1
1MR-Methods group, MBIC, Faculty of Psychology and Neuroscience, Maastricht, Netherlands, 2SFIM, NIMH, Bethesda, MD, United States, 3German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany, 4Physics and Astronomy, University of Bonn, Bonn, Germany, 5UHN Toronto, Toronto, ON, Canada

Recent developments of ultra-high field (UHF) MRI and high-resolution CBV-sensitive VASO sequences have made it possible to measure activity changes across cortical depths. However, most methods are limited to individual brain areas of large cortical thicknesses (4mm in M1), long repetition times and small matrix sizes. In this study, we developed multiple VASO sequence approaches to achieve:

1.) Whole-brain coverage (104 slices) at sub-millimeter layer resolutions

2.) Sub-second TRs (TR = 650ms) at sub-millimeter layer resolutions

3.) Extra-high 0.5mm isotropic resolutions with matrix sizes of 316

We tested new sequence concepts and validated their applicability for the neuroscientific context.

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