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Abstract #3873

Distortion- and Resolution-Matched T1w-Like Anatomy for Investigating Depth-Dependent Activity in Submillimeter-Resolution fMRI at 7T

Adnan Shah1,2, Guoxiang Liu1,2, and Takashi Ueguchi1,2
1Brain Function Analysis and Imaging Lab, CiNet, NICT, Osaka, Japan, 2Graduate School of Frontier Biosciences, Osaka University, Osaka, Japan

We demonstrate the reconstruction of isotropic submillimeter-resolution distortion- and resolution-matched (DRM) T1w-Like anatomy from the image inversion of T1-maps obtained as five slice-shifted anatomical volumes covering the whole brain. The proposed anatomy avoids the distortion-mismatch between function and anatomy resulting in a high alignment with the functional data, necessary for activity localization in submillimeter-resolution fMRI. We use the same pulse sequence for acquiring both functional and DRM anatomical images with aligned slice acquisitions except differing in parameters unrelated to distortions. Moreover, the proposed anatomy allows the generation of cortical surface for investigating depth-dependent activity in isotropic submillimeter-resolution fMRI analysis.

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