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Abstract #3874

Sensitivity of Dynamic ASL and Resting-state BOLD in Patients with Bipolar Disorder

Zongpai Zhang1, Wenna Duan1, Nicolas R. Bolo2, Carol Tamminga3, Brett A. Clementz4, Godfrey D. Pearlson5, Matcheri Keshavan2, David C. Alsop6, and Weiying Dai1
1Computer Science, State University of New York at Binghamton, Binghamton, NY, United States, 2Psychiatry, Beth Israel Deaconess Medical Center & Harvard Medical School, Boston, ME, United States, 3Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, United States, 4Psychology and Neuroscience, University of Georgia, Athens, GA, United States, 5Psychiatry, Yale University, New Haven, CT, United States, 6Radiology, Beth Israel Deaconess Medical Center & Harvard Medical School, Boston, ME, United States

The effect sizes of bipolar disorder (BD) on low frequency fluctuation (LFF) and functional connectivity (FC) using dASL and rsBOLD imaging were evaluated in forty-five subjects (19 BD patients, 26 control). dASL showed significant increase of LFF and FC in BD, while rsBOLD did not show any difference. dASL demonstrated significantly higher effect sizes compared to rsBOLD, which lead to decreases of 39% and 49% in sample size for LFF and FC measures respectively. These findings support that dASL is more sensitive to BD than rsBOLD and therefore may offer advantages in reducing costs for clinical trials of BD therapies.

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