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Abstract #3914

The amplitude of spontaneous fluctuations with high-frequency resting-state fMRI at 7T: influence of age and cardiorespiratory pulsations

Marieke van den Kerkhof1,2, Jacobus F.A. Jansen1,2,3, Lisanne P.W. Canjels1,2,3, Robert J. van Oostenbrugge2,4,5, Benedikt A. Poser6, and Walter H. Backes1,2
1Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, Netherlands, 2School for Mental Health and Neuroscience, Maastricht University, Maastricht, Netherlands, 3Department of Electrical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands, 4Department of Neurology, Maastricht University Medical Center, Maastricht, Netherlands, 5Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, Netherlands, 6Maastricht Brain Imaging Center, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, Netherlands

Resting-state fMRI with a short TR enables unaliased sampling of the BOLD-signal, by disentangling cardiorespiratory pulsation signals. In this study, we aimed to explore the feasibility of obtaining a high-frequency spectrum and determined the influence of aging. Structural and high-frequency resting-state fMRI was performed using 7T MRI on 5 young and 5 elderly subjects. The power spectra, calculated for different brain regions, showed a clear separation of spontaneous BOLD fluctuations and the respiratory and cardiac pulsations. This pilot study demonstrated the feasibility of acquiring high-frequency spectra using fMRI. Furthermore, initial results confirm that the BOLD effect attenuates with aging.

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