Abstract #3914

The amplitude of spontaneous fluctuations with high-frequency resting-state fMRI at 7T: influence of age and cardiorespiratory pulsations

Marieke van den Kerkhof^1,2, Jacobus F.A. Jansen^1,2,3, Lisanne P.W. Canjels^1,2,3, Robert J. van Oostenbrugge^2,4,5, Benedikt A. Poser⁶, and Walter H. Backes^1,2

¹Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, Netherlands, ²School for Mental Health and Neuroscience, Maastricht University, Maastricht, Netherlands, ³Department of Electrical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands, ⁴Department of Neurology, Maastricht University Medical Center, Maastricht, Netherlands, ⁵Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, Netherlands, ⁶Maastricht Brain Imaging Center, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, Netherlands

Resting-state fMRI with a short TR enables unaliased sampling of the BOLD-signal, by disentangling cardiorespiratory pulsation signals. In this study, we aimed to explore the feasibility of obtaining a high-frequency spectrum and determined the influence of aging. Structural and high-frequency resting-state fMRI was performed using 7T MRI on 5 young and 5 elderly subjects. The power spectra, calculated for different brain regions, showed a clear separation of spontaneous BOLD fluctuations and the respiratory and cardiac pulsations. This pilot study demonstrated the feasibility of acquiring high-frequency spectra using fMRI. Furthermore, initial results confirm that the BOLD effect attenuates with aging.

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