The present study is the first meta-analysis to integrate these diverse seed-based whole-brain resting-state functional connectivity (rs-FC) and voxel-based morphometry (VBM) results in bipolar disorder (BD) that exhibits abnormal connectivity within and between brain networks involved in internally oriented attention, processing of emotion or salience, goal-directed regulation of these functions, gating information, and sensorimotor processing. These findings motivate a large-scale neurocognitive model in which network abnormality is tightly linked to deficits in maintaining the integrated self (DN), processing of emotion (AN) or salience (VAN), and goal-directed regulation (FN) in BD.
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