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Abstract #3916

Insular subdivisions functional connectivity and immune dysregulation in patients with bipolar disorder: a resting‑state fMRI study

Pan Chen1, Feng Chen1, Guanmao Chen1, Long Qian2, and Ying Wang1
1Medical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou, China, 2MR Research, GE Healthcare, Beijing, China

Systemic inflammation and immune dysregulation have been considered as risk factors in the pathophysiology of mood disorders including bipolar disorder (BD). Previous metabolism, structural and functional neuroimaging studies have reported the specific regional brain volumetric alteration and dysfunction of the insula in BD. Taken together, in current study, the associations between the whole-brain dFC of each insular subdivision in unmedicated patients with BD and the level of pro-inflammatory cytokines were analyzed. Our results demonstrated that the clinical risk factors might relate to the aberrant dFC in specific insular subdivision.

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