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Abstract #3919

Abnormal Stationary and Dynamic Functional Connectivity in Multiple System Atrophy

Weimin Zheng1, Xiang Feng2, and Zhiqun Wang1
1Aerospace Center Hospital, Beijing, China, 2MR Scientific Marketing, Diagnosis Imaging, Siemens Healthcare Ltd, Beijing, China

This study aims to explore whether the differences in static and dynamic functional connectivity (s-FC and d-FC) can serve as potential biomarkers of multiple system atrophy (MSA). 24 MSA patients and 20 normal controls (NCs) were enrolled. We applied both s-FC and d-FC to evaluate functional changes in MSA patients and calculated the graph theory attributes based on s-FC and d-FC. We found that there were significant correlations between indicators of s-FC and d-FC and clinical performance. Furthermore, the receiver operating characteristic (ROC) analysis revealed that the substantially different FC features can serve as predictors to distinguish MSA from NC.

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