In this study, the whole brain temporal variability (TV) changes have been respectively investigated for patients with subjective cognitive decline (SCD) and mild cognitive impairment (MCI) and healthy controls (HCs). Significantly different TVs have been separately found between SCD, MCI patients and HCs in the regions involved in executive function, episodic memory, visual processing and visual memory and language perception and processing. Additionally, the TVs at these regions also showed strong correlations with multiple clinical scales. Therefore, TV method can be considered an effective tool in the early detection of SCD patients.
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