Meeting Banner
Abstract #3927

Improving brain imaging in Parkinson's disease by accounting for simultaneous motor output.

Renzo Torrecuso1, Karsten Mueller1, Stefan Holiga2, Thomas Sieger3, Jan Vymazal4, Růžička Jan5, Evzem Ruzicka6, Matthias Schroeter7, Robert Jech8, and Harald E. Möller1
1Nuclear Magnetic Resonance, Max Planck Institute for Human Brain and Cognitive Sciences, Leipzig, Germany, 2Roche Pharma Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland, 3Department of Neurology and Center of Clinical Neuroscience, , Charles University in Prague, Prague, Czech Republic, 4| CULS · Faculty of Environmental Science, Czech University of Life Sciences Prague, Prague, Czech Republic, 5Department of Environmental Engineering, Faculty of TechnologyTomas Bata University in Zlín, Zlin, Czech Republic, 6Neurology, General University Hospital in Prague, Prague, Czech Republic, 7Clinic for Cognitive Neurology, University Hospital Leipzig, Leipzig, Germany, 8Department of Neurology, Charles University in Prague | CUNI ·, Prague, Czech Republic

Parkinson's disease leads to a variety of movement impairments. While studying the disease with fMRI, the main motivation for the research becomes one of its major obstacles: the motor output is unpredictable. Therefore it is troublesome to access, inside the scanner, performances of motor tasks and reliably relate them to brain measurements. We proposed to overcome this by expanding the patients’ number and restricting statistical criteria from a previous study which used a glove with non-magnetic sensors during scanning. Our results revealed basal ganglia not observed in the previous study confirming the usefulness of the device in fMRI studies.

This abstract and the presentation materials are available to 2020 meeting attendees and eLibrary customers only; a login is required.

Join Here