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Abstract #3928

Behavior-related resting-state MEG/fMRI connectivity changes are related to the hierarchical organization of the neocortex

Feng Han1 and Xiao Liu1,2
1Department of Biomedical Engineering, Pennsylvania State University, State College, PA, United States, 2Institute for Cyber Science, Pennsylvania State University, State College, PA, United States

It has been shown that the maximal correlation between rsfMRI connectivity and behavioral measures occurs along a positive-negative mode direction characterizing the change of the overall goodness of behavior. Here, we had a thorough examination of rsfMRI/MEG connectivity along this positive-negative mode direction. We found that behavioral changes are associated with significant connectivity modulations that are however distinct at the lower-order sensory/motor areas and higher-order cognitive regions. Moreover, this hierarchy-dependent connectivity modulation is similar for rsfMRI and middle-frequency MEG signals, but reversed for gamma-band MEG signals. The findings may provide novel insight into the neural basis of inter-subject behavioral variability.

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