Abstract #3943

Chemically-Induced Hypothermia Altered Hypothalamic Functional Connectivity with Limbic System in the Monkey Brain

Chun-Xia Li¹, Xiaohuan Gu², Doty Kempf¹, Ling Wei², Shanping Yu^3,4, and Xiaodong Zhang^1,5

¹Yerkes Imaging Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA, United States, ²Department of Anesthesiology, Emory University School of Medicine, Atlanta, GA, United States, ³2Department of Anesthesiology, Emory University School of Medicine, Atlanta, GA, United States, ⁴Center for Visual and Neurocognitive Rehabilitation, , Atlanta Veterans Affairs Medical Center, Decatur, GA, United States, ⁵Division of Neuropharmacology and Neurologic Diseases, Yerkes National Primate Research Center, Emory University, Atlanta, GA, United States

Rhesus monkeys were used to investigate whether ABS-201 induces similar hypothermia effect in large animals as seen in rodents and how this drug influences the hypothalamus centered limbic functional network. Functional connectivity (FC) between anterior hypothalamus and limbic system was examined by using resting state fMRI (rsfMRI). It is found that ABS-201 caused significant hypothermia effects in monkeys and significantly decreased hypothalamic FC with limbic regions as well. The findings suggest ABS-201 may have profound effects on the neurobehavior of subjects mediated by the hypothermia and antipsychotic effect.

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