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Abstract #3944

Characterizing the morphology and resting-state functional connectivity in chronic specific and nonspecific low back pain

Cui Ping Mao1, Quan Xin Yang1, Qiu Juan Zhang1, Hong Hong Sun1, Hua Juan Yang1, Xiao Qian Zhou1, and Gui Rong Zhang1
1Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China

It is important to determine and distinguish the mechanisms underlying different types of pain because different drug targets are useful in pain of different origins. Specific low back pain (SLBP) with a recognizable pathology and nonspecific low back pain (NSLBP) are different pain conditions. The amygdala has been linked with the pathophysiology of chronic LBP. However, it is not known whether the amygdala is differentially affected in both conditions. Our study suggested that the amygdala morphology, resting-state functional connectivity and effective connectivity are differentially affected in subjects with SLBP and NSLBP, indicating different brain mechanisms in SLBP and NSLBP.

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