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Abstract #3946

Muscone-evoked activations in the whole brains of mice, studied by the BOLD method using periodic stimulation and independent component analysis

Fuyu Hayashi1, Mitsuhiro Takeda1, Naoya Yuzuriha1, Sosuke Yoshinaga1, and Hiroaki Terasawa1
1Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan

Muscone is a compound that contributes to the smell of musk and attracts male mice. When mice are stimulated with muscone, their main olfactory bulb and olfactory cortex are activated, as revealed by immunohistochemistry. It is conceivable that the signals are further transduced in the cerebrum, resulting in the attraction behavior in male mice. It is important to identify the muscone-evoked activated regions in the whole brain and explore their biological significance. We previously developed a functional MRI method that uses repetitive odor stimulation and independent component analysis. We applied this method to identify the muscone-evoked activated regions.

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